Table 3.

Anti-oxidative and NF-kB inhibitory drugs used in preclinical/clinical studies

Drug/compound	Company	Status	Mode of Action
Antioxidants
N-acetylcysteine (NAC)	*Twinlabs	Preclinical	Antioxidant
Green tea extract (Epigallocatechin-Gallate; EGCg)	*Nature’s Way	Clinical trials	Antioxidant
Melatonin	*GNC	Clinical trials	Antioxidant
Idebenone	Santhera Pharmaceuticals	Clinical trials	Antioxidant
NF-kB inhibition
Remicade	Merck/Schering-Plough	Preclinical	Antibody to human TNF-α
Etanercept	Wyeth	Preclinical	Blocks soluble receptor to TNF-α
NBD peptide	**Enzo Life Science	Preclinical	Inhibitor of the NF-κB signaling pathway

^*Available over the counter from several sources (e.g., NOW Foods, FoodScience of Vermont)

^**Clinical grade product not available