TABLE 3.
Toxicities*
| Adverse events | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Allergic rhinitis | 8 | 9 | — | — |
| Hemoglobin decrease | 43 | 28 | 5 | — |
| Leukopenia | 8 | 21 | — | 1 |
| Thrombocytopenia | 33 | 39 | 20 | 3 |
| Edema | 41 | 47 | 2 | — |
| Hypotension | 2 | 34 | 99 | 5 |
| Myocardial ischemia | — | 2 | 3 | 1 |
| Myocarditis | — | — | 1 | — |
| Arrhythmia (ie, SVT, etc) | 56 | 10 | 11 | 3 |
| Chills | 1 | 53 | 34 | — |
| Fatigue | 20 | 63 | 34 | — |
| Rash | 26 | 32 | 16 | 2 |
| Ascites | 3 | 7 | — | — |
| Diarrhea | 38 | 26 | 58 | — |
| Mucositis | 21 | 13 | 3 | — |
| Nausea | 21 | 59 | 56 | 3 |
| Vomiting | — | 1 | — | — |
| Melena/GI bleed | — | 1 | — | — |
| Hematuria | 3 | — | — | — |
| Hemorrhage | 5 | 1 | 1 | 2 |
| Infection | 2 | 5 | 9 | 3 |
| Catheter infection | — | — | 4 | 4 |
| Increased AST | 50 | 19 | 5 | — |
| Hyperbilirubinemia | 62 | 78 | 15 | — |
| Hypocalcemia | — | — | 1 | — |
| Increased creatinine | 62 | 47 | 5 | — |
| Confusions | 11 | 15 | 21 | 14 |
| Hallucinations | — | — | 1 | — |
| Depressed level of consciousness | 8 | 8 | 13 | 8 |
| Respiratory disorder | 14 | 48 | 17 | 8 |
| Pleural effusion | 4 | 13 | 3 | — |
| Low urine output due to CLS | — | — | 38 | 11 |
| Renal failure | — | — | 1 | — |
SVT indicates supraventricular tachycardia; GI, gastrointestinal; AST, aspartate aminotransferase; CLS, capillary leak syndrome.
*
Determined according to the National Cancer Institute Common Toxicity Criteria grading system.