Fig 7.

BJCA08/CA16 pretreated in vitro with anti-G10/CA16 serum could significantly lose its lethal effect in neonatal mice. Serially diluted anti-G10 serum (NTAb titer, 1,280) or medium was incubated with an equal volume of 300 PFU BJCA08 at 37°C for 1 h. One-day-old ICR mice (n = 8 to 10 per group) were intracerebrally inoculated with the mixture described above. Mortality and clinical disease were monitored and recorded daily after infection. The Mantel-Cox log-rank test was used to compare the survival of pups between each antiserum group and the medium control group at 21 days postinfection. ***, P < 0.0001; **, P < 0.001.