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. 2012 Nov;86(22):12138–12147. doi: 10.1128/JVI.00375-12

Fig 2.

Fig 2

Dengue virus infects systemic nonlymphoid tissues late during infection. Representative immunohistochemical staining of tissue sections from AG129 mice. (A) Tissues were harvested from naïve mice and mice 48 and 72 h after infection (1.5 × 1011 GE of the DENV2 strain E124/128-IC i.v. on day 0) and stained for DENV NS3 (white) in the kidney, heart, thymus, adrenal gland, liver, lung, forestomach, stomach, duodenum, jejunum, ileum, cecum, colon, and rectum. The results are representative of 3 mice. (B) Tissues were harvested from mice 6, 24, and 72 h after infection (1.5 × 1011 GE of the DENV2 strain E124/128-IC i.f. on day 0) and stained for DENV NS3 (white) in the spleen, draining popliteal lymph node (drPLN), contralateral popliteal lymph node (clPLN), cutaneous lymph nodes (CLNs: axillary, brachial, and inguinal lymph nodes), and kidney. The results are representative of 3 mice.