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LMP1-induced sumoylation of IRF7 inhibits IRF7 turnover. 293T cells were transfected as indicated, and 18 h before harvesting, cells were treated with DMSO, cycloheximide (CHX) (75 μg/ml), or MG132 (50 μM). Cell lysates were harvested 48 h posttransfection and immunoblotted to determine IRF7 and LMP1 levels. Actin was used as a loading control. Densitometry was used to determine relative protein levels (normalized to actin). Data are shown as means ± SD.
