Table 5.
Differences in the rate of escape in participants positive for the HLA- B7 supertype and Cw*08:02 alleles that target TL9 epitope
| Timea (mo postinfection) | No. of participants with indicated alleleb |
||||
|---|---|---|---|---|---|
| B*39:10 (n = 2) | B42 (n = 14) | B*07:02 (n = 4) | B*81:01 (n = 5) | Cw*08:02 (n = 1) | |
| Enrollment | 1 and 1* | 0 | 0 | 1* | 0 |
| <3 | 0 | 0 | 0 | 0 | 0 |
| 3–6 | 0 | 0 | 0 | 0 | 0 |
| 6–12 | 1* | 1† | 0 | 1 and 1* | 0 |
| 12–18 | 0 | 1‡ | 0 | 2 | 0 |
The time corresponds to when the first mutation was observed in TL9 epitope in the CAPRISA (AI02) cohort.
*, Participants with mutation at enrollment but with later further evolution of the mutation; †, mutation Q182T; ‡, mutation L188F was transient.