Table 6.

Mutational analysis to locate amino acid residues responsible for differences in sensitivity/resistance to neutralization by HIV-positive sera possessing broadly neutralizing antibodies^a

Subject or virus	Clone	Phenotype or mutation	Neutralization titer (IC50) of HIV-positive serum (1/dilution)
			Z23	N16	Z1679
108069	005	wtR	196	40	<20
	011	wtS	581	161	120
	005	H105Q	214	45	45
	005	G263S	252	38	38
	005	Y330H	263	48	29
	005	N407Y/Y409N/ΔK410/E411T/K412G	267	25	37
	005	R440S/I447S	314	45	44
	005	N464D	215	23	40
	005	A612T	192	33	<20
	005	E630Q	259	<20	38
	005	S668G	258	58	30
	005	I675V	342	45	103
	005	S668G/I675V	477	62	323
	005	V817/A820/I832V/A836I	196	49	<20
JRCSF			358	269	273
NL4-3			4,416	1,431	3,155
aMLV			<100	<20	<20

^aRefer to the footnote to Table 3 for details.