Polyreactivity profiles of antibodies derived from EBV− memory B cells. Antibodies were tested for polyreactivity by ELISA with dsDNA, ssDNA, insulin, and LPS. Each black line represents an independent antibody. Controls for polyreactivity included high-polyreactivity positive-control antibody ED38 (dotted line), low-polyreactivity positive-control antibody eiJB40 (red line), and negative-control antibody mG053 (green line). Antibodies with absorbances comparable to or higher than that of low-polyreactivity positive-control antibody eiJB40 against more than one antigen were scored as polyreactive.