Fig 4.

HMPV infection depends upon α5β1 and αV integrins. HMPV infection at 24 h was determined in the absence or presence of αV, α5, or a combination of the two integrin function-blocking antibodies. Infected cells were enumerated as described in Materials and Methods. Results from at least three independent experiments performed in triplicate are expressed as mean percent inhibition relative to untreated control (no MAb); error bars indicate SEM. *, additive effect of combination blockade on HMPV infectivity; Student's t test comparing two treatments, P ≤ 0.05.