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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Invest New Drugs. 2010 Oct 12;30(2):629–638. doi: 10.1007/s10637-010-9563-7

Table 3. Frequency of symptoms in patients developing CKRS.

Symptoms Total no. of CKRS
No. of events=23
Grade 1 CKRS
No. of events=4
Grade 2 CKRS
No. of events=13
Grade 3 CKRS
No. of events=6
Fever 4% 25% 0 0
Sinus tachycardia 52% 25% 62% 50%
Hypotension 35% 0 38% 50%
Dizziness 39% 75% 31% 35%
Diaphoresis 48% 75% 23% 83%
Syncope 13% 25% 15% 0
Tumor pain 13% 0 15% 17%
Flushing 4% 0 0 17%
Confusion/disorientation 17% 25% 0 50%
Nausea/Vomiting 35% 25% 38% 33%
Rigors/cold extremities 22% 25% 15% 33%
Diarrhea 13% 0 8% 33%