Table 2.
Geometric mean determined from the results of at least 3 independent experiments for the 50% inhibitory concentration (IC50) of the five dyes presenting the best antiplasmodial activity against human HeLa cells
| Dye | Cytotoxicity IC50 ± SD (nM) on HeLa cells | SIa |
|||
|---|---|---|---|---|---|
| HC/3D7 (day 3) | HC/3D7 (day 6) | HC/Dd2 (day 3) | HC/Dd2 (day 6) | ||
| Hoechst 33342 | 1,357 ± 184.8 | 188 | 72 | 83 | 48 |
| MitoRed | 2,666 ± 1,238 | 325 | 251 | 168 | 423 |
| DiOC6 | 2,727 ± 1,831 | 239 | 158 | 131 | 16 |
| SYTO 9 | 3,287 ± 1,141 | 160 | 142 | 91 | 671 |
| Rhodamine B | 4,372 ± 710.0 | 212 | 228 | 168 | 63 |
a
SI, selectivity index (calculated as the ratio of the IC50 against HeLa cells [HC] to the IC50 against culture-adapted strains of P. falciparum 3D7 and Dd2).