Table 3.
Differential gene expression in Lcn972-resistant L. lactis D1 and its parent, L. lactis MG1614
| Category, locus tag, and gene | Ratioa | Bayesian Pb | Functionc |
|---|---|---|---|
| Carbohydrate/amino acid transport and metabolism | |||
| llmg0187, celB | −3.99 | 1.12E-04 | Cellobiose-specific PTS system IIC component |
| llmg0437, ptcB | −2.57 | 1.06E-08 | Cellobiose-specific PTS system IIB component |
| llmg0454 | −3.38 | 9.67E-11 | β-Glucoside-specific PTS system IIABC component |
| llmg0458 | −5.60 | 1.47E-11 | Putative glucosyltransferase |
| llmg0739, malE | −6.35 | 3.91E-13 | Maltose ABC transporter substrate binding protein |
| llmg0740, dexC | −3.91 | 4.71E-12 | Neopullulanase |
| llmg0741, dexA | −3.75 | 1.61E-04 | Oligo-1,6-α-glucosidase |
| llmg0743, amyY | −2.55 | 2.84E-05 | α-Amylase |
| llmg0745, mapA | −6.35 | 4.58E-09 | Maltose phosphorylase |
| llmg0749, dxsB | −6.05 | 4.94E-14 | 1-Deoxy-d-xylulose-5-phosphate synthase |
| llmg0751, ascB | −12.72 | 5.21E-14 | 6-Phospho-β-glucosidase |
| llmg1048, busAA | 2.68 | 4.54E-14 | Glycine betaine/proline ABC transporter |
| llmg1049, busAB | 3.00 | 1.07E-12 | Glycine betaine-binding periplasmic protein |
| llmg1164 | 2.77 | 5.74E-04 | Putative sugar ABC transporter permease |
| llmg1869, apu | 8.42 | 3.33E-16 | Amylopullulanase |
| llmg1871, glgP | 6.91 | 2.22E-16 | Glycogen phosphorylase |
| Signal transduction/regulatory mechanisms | |||
| llmg0746, malR | −25.19 | 3.33E-16 | Maltose operon transcriptional repressor |
| llmg0747, llrF | −10.33 | 5.66E-15 | Two-component system regulator LlrF |
| llmg0748, kinF | −5.83 | 3.03E-12 | Sensor protein kinase KinF |
| llmg2163 | 2.24 | 2.73E-11 | Hypothetical protein, PspC domain |
| llmg2164 | 2.86 | 1.15E-12 | Hypothetical protein |
| llmgpseudo76, sigX | 13.15 | 2.89E-15 | ECF sigma factor |
| llmg2447 | 37.56 | 1.47E-14 | Putative anti-ECF sigma factor |
| Miscellaneous | |||
| llmg0619 | 2.58 | 7.14E-13 | Hypothetical protein |
| llmg0669 | −5.35 | 8.07E-10 | Hypothetical protein |
| llmg0752, pip | −3.08 | 1.20E-09 | Phage infection protein |
| llmg1271, gidC | −2.66 | 4.94E-09 | tRNA (uracil-5-)-methyltransferase Gid |
| llmg1679, pbpX | 6.21 | 1.73E-14 | Penicillin-binding protein |
| llmg2353, rplQ | −31.81 | 4.44E-16 | Ribosomal protein L17 |
| llmg2409, polC | 2.86 | 5.23E-13 | DNA polymerase III PolC |
a
Values for genes whose expression changes >2.5-fold are shown. Negative values indicate downregulation.
b
Determined by Cyber-T test (24).
c
According to GenBank accession number AM406671.1.