Table 7.
Incidence of potentially clinically significant laboratory abnormalities
| Laboratory abnormality | No. of occurrences in treatment group |
|
|---|---|---|
| TD-1792 (n = 98) | Vancomycin (n = 99) | |
| Hematology | ||
| Hemoglobin (male, <10 g/liter) | 1 | 0 |
| WBC (<2.8 × 109/liter) | 0 | 1 |
| Eosinophils (≥10%) | 2 | 1 |
| Platelet count (<75 × 109/liter) | 1 | 0 |
| Chemistry | ||
| Potassium (<3.0 mmol/liter) | 1 | 1 |
| Potassium (>5.5 mmol/liter) | 3 | 1 |
| Calcium (<1.5 mmol/liter) | 2 | 0 |
| Chloride (>115.0 mmol/liter) | 2 | 1 |
| Serum creatinine (>177 mmol/liter) | 0 | 1 |
| BUN (>11mmol/liter) | 2 | 1 |
| Serum creatinine (≥133 mmol/liter and 50% greater than baseline) | 0 | 1 |
| Liver function tests | ||
| SGOT/AST (≥3× ULN) | 3 | 3 |
| SGPT/ALT (≥3× ULN) | 2 | 3 |
| Total bilirubin (≥1.5× ULN) | 0 | 0 |
WBC, white blood count; BUN, blood urea nitrogen; SGOT, serum glutamic oxaloacetic transaminase; SGPT, serum glutamic pyruvic transaminase; ULN, upper limit norm.