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Efficacy of AFN-1252 in a mouse sepsis model. The in vivo efficacy of AFN-1252 was demonstrated in an acute lethal mouse S. aureus Smith infection model. Thirty minutes after intraperitoneal inoculation with a lethal dose of S. aureus Smith, an oral dose of AFN-1252 or linezolid was administered and percent survival was recorded over 5 days.
