Table 2.

Effects of AFN-1252 and reference antibacterials on incorporation of radiolabeled precursors into S. aureus 29213 cells

Precursor	Synthesis pathway	Normalized % precursor incorporationa
		Vancomycin	Levofloxacin	Rifampin	Tetracycline	Triclosan	AFN-1252
N-Acetylglucosamine	Cell wall	19	95	73	82	85	90
Thymidine	DNA	101	35	113	75	89	101
Uridine	RNA	58	93	22	103	99	106
Isoleucine	Protein	62	81	61	22	59	61
Acetate	Lipid	42	86	97	55	36	24

^aA value of 100% represents the untreated control. Bold values are reference or specific antibacterials for each synthesis pathway.