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Pharmacokinetics of AFN-1252 (free base) in mice following oral administration
| AFN-1252 dose (mg/kg) | Cmax (ng/ml) | Tmaxa (h) | AUC0-t (ng-h/ml) | AUC0-∞b (ng-h/ml) | Elimination half-life (h) |
|---|---|---|---|---|---|
| 0.3 | 154 | 0.5 | 367 | 545 | 4.6 |
| 0.6 | 196 | 0.5 | 806 | 1,402 | 7.2 |
| 1 | 304 | 1 | 1,030 | 1,683 | 6.8 |
Tmax, time to maximum concentration of drug in serum.
AUC0-∞, AUC from 0 h to infinity.
