Table 1.
MICs of T-2307 and reference agents in YPD or YPG
| Strain | MIC (μg/ml)a |
|||||
|---|---|---|---|---|---|---|
| T-2307 |
Pentamidine |
Amphotericin B |
||||
| YPD | YPG | YPD | YPG | YPD | YPG | |
| Candida albicans ATCC 90028 | >16 | 0.002 | >32 | 1 | 2 | 1 |
| Saccharomyces cerevisiae ATCC 24657 | >16 | 0.001 | >32 | 0.5 | 1 | 1 |
| Cryptococcus neoformans ATCC 90112 | 0.0039 | 0.0039 | 2 | 1 | 1 | 1 |
a
Cells were incubated at 30°C for 48 h (C. albicans and S. cerevisiae) or for 72 h (C. neoformans). YPD, yeast extract-peptone containing 2% dextrose; YPG, yeast extract-peptone containing 2% glycerol.