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. 2012 Nov;56(11):6033–6036. doi: 10.1128/AAC.01250-12

Table 1.

MICs of macrolide antibiotics that prevent growth of Gram-negative strainsa

Strain MIC (μg/ml) of macrolide
Tylosin Tilmicosin Tildipirosin Tulathromycin
M. haemolytica 11935 64 4 0.5 2
P. multocida 4407 32 4 1 0.5
E. coli ATCC 25922 512 128 16 16
E. coli AS19rlmAI 1 2 0.5 1
a

P. multocida 4407 and M. haemolytica 11935 are susceptible strains that contain none of the macrolide resistance determinants (4, 19). E. coli ATCC 25922 also lacks any resistance determinants and is a wild-type strain with regard to cell wall/membrane structures. The hyperpermeable strain AS19rlmAI is described in Table 2. Quality controls were included as previously described (19).