Table 1.

HSV isolates assessed in this study^a

Isolate	Type	Gender/age (yr)	Anatomical location of lesion	EC50 of acyclovir	EC50 of foscarnet
Acyclovir-sensitive HSV
HSV-1	1	M/22	Orolabial	1.6 μMb	NDc
HSV-2	2	F/24	Genital	1.6 μMb	ND
Acyclovir-resistant HSV
DE-5016	1	M/61	Corneal	>80 μM	80 μM
DE-625	2	M/60	Knee pit	>80 μM	ND
DE-3657	2	F/52	Genital	>80 μM	30 μM
DE-6820	2	F/83	Genital	80 μM	50 μM
DE-14574	2	F/82	Genital	>80 μM	125 μM

^aThe acyclovir-resistant isolates were analyzed with a plaque assay at Sahlgrenska University Hospital, Gothenburg, Sweden. The reference values for acyclovir and foscarnet resistance were >4 μM and >160 μM, respectively.

^bEC₅₀s as presented in Fig. 3, analyzed by qPCR.

^cND, not determined.