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Activity of tested regimens in the in vitro pharmacokinetic/pharmacodynamic model of simulated endocardial vegetations. Closed squares, daptomycin plus trimethoprim-sulfamethoxazole (DSXT) for 14 days; open triangle, DSXT for 7 days followed by SXT for 7 days; open circles, DSXT for 7 days followed by daptomycin at 10 mg/kg/day (D10) for 7 days; closed circles, D10 for 14 days; closed triangles, SXT for 14 days; open squares, growth control.
