Table 2.

Activity of tested regimens in the in vitro pharmacokinetic/pharmacodynamic model^a

Isolate	Time (h) to 99.9% kill					Change in log10 CFU/g at:
						168 h					336 h
	DAP	SXT	DSXT	−DAP	−SXT	DAP	SXT	DSXT	−DAP	−SXT	DAP	SXT	DSXT	−DAP	−SXT
SA H	14	NA	7	7	7	5.35	2.65	8.34	8.34	8.34	5.11	2.54	8.84	7.94	8.75
R6212	NA	NA	6	6	6	2.98	0.67	8.33	8.33	8.33	1.44	1.65	8.81	8.81	8.49
R5599	336	NA	72	72	72	1.48	0.58	8.93	8.93	8.93	3.7	1.31	8.93	8.93	8.93
R5563	32	NA	36	36	36	4.47	0.42	8.21	8.21	8.21	4.43	0.98	8.88	8.69	8.88

^aTime to 99.9% kill refers to the time to bactericidal activity sustained at 336 h. DAP, daptomycin at 10 mg/kg/day for 14 days; SXT, trimethoprim-sulfamethoxazole for 14 days; DSXT, daptomycin plus trimethoprim-sulfamethoxazole for 14 days; −DAP, daptomycin plus trimethoprim-sulfamethoxazole for 7 days followed by daptomycin for 7 days; −SXT, daptomycin plus trimethoprim-sulfamethoxazole for 7 days followed by trimethoprim-sulfamethoxazole; SA H, SA H9749-1; NA, not applicable.