Table 3.
Steady-state pharmacokinetic parameters of linezolid in plasmaa
| Parameter | Value for the parameter by linezolid dosea |
|
|---|---|---|
| 300 mg (n = 3) | 600 mg (n = 5) | |
| AUC0–12 (mg · h/liter) | 50.9 (50.5–54.9) | 126.9 (121.6–127.6) |
| Cmax (mg/liter) | 8.8 (7.8–8.9) | 16.5 (14.4–16.5) |
| Tmax (h) | 1.9 (1.9–4.8) | 1.9 (1.7–3.0) |
| t1/2 (h) | 4.6 (4.0–6.9) | 7.5 (7.3–7.9) |
| Cl (liters/h) | 4.9 (3.8–5.1) | 3.1 (3.0–3.1) |
| Vd (liters) | 32.6 (29.4–34.4) | 34.8 (32.9–41.6) |
a
Data are presented as medians (IQR). All patients (n = 8) received linezolid twice daily.