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Light microscopy of olfactory bulbs in mice infected with N. fowleri and treated with PBS. (A) Olfactory bulbs show a mixed-cell inflammatory reaction with many neutrophils. Necrotic brain tissue is evident. Magnification, ×10. (B) Higher-magnification view of the same area, showing trophozoites (arrowheads) and polymorphonuclear cells (arrows). Magnification, ×60. The tissues were stained with hematoxylin and eosin.
