Table 1.
Sequences and characteristics of LL-37 and some of its truncated fragmentsa
| Peptide | Alternative name | Amino acid sequence | MW | MIC (μM) | MBC (μM) | Agadir |
|---|---|---|---|---|---|---|
| LL-37 | LL-37 | LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES | 4,494 | 25 | >100 | 5.10 |
| LL-31 | LL-31 | LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNL | 3,824 | 50 | >100 | 3.72 |
| LL-25 | LL-25 | LLGDFFRKSKEKIGKEFKRIVQRIK | 3,065 | >100 | >100 | 1.19 |
| LL-19 | LL-19 | LLGDFFRKSKEKIGKEFKR | 2,327 | >100 | >100 | 0.92 |
| LL-13 | LL-13 | LLGDFFRKSKEKI | 1,581 | >100 | >100 | 0.84 |
| LL7-31 | RK-25 | RKSKEKIGKEFKRIVQRIKDFLRNL | 3,131 | 100 | >100 | 4.06 |
| LL13-31 | IG-19 | IGKEFKRIVQRIKDFLRNL | 2,374 | 100 | >100 | 4.33 |
| LL7-25 | RK-19 | RKSKEKIGKEFKRIVQRIK | 2,372 | >100 | >100 | 0.73 |
| LL13-25 | IG-13 | IGKEFKRIVQRIK | 1,615 | >100 | >100 | 0.71 |
| LL7-37 | RK-31 | RKSKEKIGKEFKRIVQRIKDFLRNLVPRTES | 3,801 | 50 | >100 | 5.68 |
| LL13-37 | IG-25 | IGKEFKRIVQRIKDFLRNLVPRTES | 3,044 | >100 | >100 | 5.87 |
| LL19-37 | RI-19 | RIVQRIKDFLRNLVPRTES | 2,341 | >100 | >100 | 2.08 |
| LL25-37 | KD-13 | KDFLRNLVPRTES | 1,575 | >100 | >100 | 0.09 |
a
The MIC and the MBC have been determined as described in Materials and Methods. The Agadir index has been calculated using the helix/coil transition program AGADIR (22).