Table 4.
Dosage regimen | Elimination modela | PTA expectation value (%) |
||
---|---|---|---|---|
E. coli (n = 51,561) | K. pneumoniae (n = 21,507) | P. aeruginosa (n = 31,535) | ||
Daily dose: 6 g piperacillin as continuous infusion | 1 | 93.8 | 83.7 | 68.6 |
2 | 93.1 | 82.1 | 65.2 | |
3 | 93.2 | 82.4 | 65.9 | |
4 | 92.9 | 81.8 | 64.4 | |
Daily dose: 9 g piperacillin 3 g q8h as 4-h infusions | 1 | 95.2 | 86.6 | 75.3 |
2 | 94.9 | 85.9 | 73.8 | |
3 | 95.1 | 86.4 | 74.7 | |
4 | 95.0 | 86.1 | 74.2 | |
Daily dose: 18 g piperacillin as continuous infusion | 1 | 96.8 | 89.4 | 81.7 |
2 | 96.7 | 89.2 | 81.3 | |
3 | 96.8 | 89.4 | 81.7 | |
4 | 96.8 | 89.4 | 81.7 | |
Daily dose: 12 g piperacillin as 4 g q8h, 0.5-h infusions | 1 | 85.9 | 67.8 | 41.1 |
2 | 88.7 | 72.4 | 47.1 | |
3 | 83.3 | 66.1 | 42.6 | |
4 | 86.3 | 70.0 | 46.6 | |
Daily dose: 18 g piperacillin as 6 g q8h, 0.5-h infusions | 1 | 90.2 | 76.0 | 53.8 |
2 | 92.7 | 81.2 | 63.5 | |
3 | 89.7 | 76.1 | 56.3 | |
4 | 91.9 | 79.8 | 62.1 | |
Daily dose: 16 g piperacillin as 4 g q6h, 0.5-h infusions | 1 | 93.0 | 81.8 | 64.9 |
2 | 93.8 | 83.6 | 68.5 | |
3 | 92.4 | 81.0 | 64.2 | |
4 | 93.3 | 82.5 | 66.8 |
See Table 2 for further details on the four elimination models.