Table 4.

PTA expectation values for piperacillin versus E. coli, K. pneumoniae, and P. aeruginosa (EUCAST) based on the PK/PD target fT_>MIC of ≥50% for the four elimination models

Dosage regimen	Elimination modela	PTA expectation value (%)
		E. coli (n = 51,561)	K. pneumoniae (n = 21,507)	P. aeruginosa (n = 31,535)
Daily dose: 6 g piperacillin as continuous infusion	1	93.8	83.7	68.6
	2	93.1	82.1	65.2
	3	93.2	82.4	65.9
	4	92.9	81.8	64.4
Daily dose: 9 g piperacillin 3 g q8h as 4-h infusions	1	95.2	86.6	75.3
	2	94.9	85.9	73.8
	3	95.1	86.4	74.7
	4	95.0	86.1	74.2
Daily dose: 18 g piperacillin as continuous infusion	1	96.8	89.4	81.7
	2	96.7	89.2	81.3
	3	96.8	89.4	81.7
	4	96.8	89.4	81.7
Daily dose: 12 g piperacillin as 4 g q8h, 0.5-h infusions	1	85.9	67.8	41.1
	2	88.7	72.4	47.1
	3	83.3	66.1	42.6
	4	86.3	70.0	46.6
Daily dose: 18 g piperacillin as 6 g q8h, 0.5-h infusions	1	90.2	76.0	53.8
	2	92.7	81.2	63.5
	3	89.7	76.1	56.3
	4	91.9	79.8	62.1
Daily dose: 16 g piperacillin as 4 g q6h, 0.5-h infusions	1	93.0	81.8	64.9
	2	93.8	83.6	68.5
	3	92.4	81.0	64.2
	4	93.3	82.5	66.8

^aSee Table 2 for further details on the four elimination models.