Table 2.
Substrate | Parameters fora: |
|||||
---|---|---|---|---|---|---|
KPC-3 |
KPC-9 |
|||||
Km (μM) | kcat (s−1) | kcat/Km (μM−1 s−1) | Km (μM) | kcat (s−1) | kcat/Km (μM−1 s−1) | |
Piperacillin | 50 ± 5 | 7.1 ± 4.3 | 0.14 ± 0.1 | 61 ± 19 | 8.5 ± 1.5 | 0.14 ± 0.07 |
Ceftriaxone | 122 ± 19 | 29.1 ± 1 | 0.24 ± 0.05 | 104 ± 3 | 29.5 ± 1.2 | 0.28 ± 0.01 |
Ceftazidime | 168 ± 33 | 37.9 ± 3.5 | 0.23 ± 0.03 | 32 ± 6 | 47.4 ± 5.3 | 1.47 ± 0.05 |
Ertapenem | 177 ± 41 | 47.5 ± 10.9 | 0.27 ± 0.11 | 221 ± 56 | 52.8 ± 5.4 | 0.24 ± 0.08 |
Imipenem | 26 ± 6 | 110.1 ± 4.2 | 4.24 ± 0.13 | 34 ± 9 | 101.5 ± 11.9 | 3.02 ± 0.7 |
Values are means and standard deviations.