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. 2012 Nov;56(11):6057–6059. doi: 10.1128/AAC.01156-12

Table 2.

Kinetic parameters for KPC-3 and KPC-9

Substrate Parameters fora:
KPC-3
KPC-9
Km (μM) kcat (s−1) kcat/Km (μM−1 s−1) Km (μM) kcat (s−1) kcat/Km (μM−1 s−1)
Piperacillin 50 ± 5 7.1 ± 4.3 0.14 ± 0.1 61 ± 19 8.5 ± 1.5 0.14 ± 0.07
Ceftriaxone 122 ± 19 29.1 ± 1 0.24 ± 0.05 104 ± 3 29.5 ± 1.2 0.28 ± 0.01
Ceftazidime 168 ± 33 37.9 ± 3.5 0.23 ± 0.03 32 ± 6 47.4 ± 5.3 1.47 ± 0.05
Ertapenem 177 ± 41 47.5 ± 10.9 0.27 ± 0.11 221 ± 56 52.8 ± 5.4 0.24 ± 0.08
Imipenem 26 ± 6 110.1 ± 4.2 4.24 ± 0.13 34 ± 9 101.5 ± 11.9 3.02 ± 0.7
a

Values are means and standard deviations.