Table 2.
AS dose (mg/kg) | No. of subjects | Day 0 |
Day 6 |
Day 0 compared to day 6 |
|||
---|---|---|---|---|---|---|---|
AUC0–6a | AUC2–6 | AUC0–6 | AUC2–6 | AUC0–6 | AUC2–6 | ||
2 | 73 | 1,067 | 652 | 554 | 330 | 1.93 | 1.97 |
4 | 38 | 2,853 | 1,801 | 1,263 | 775 | 2.26 | 2.33 |
6 | 25 | 4,850 | 3,221 | 1,394 | 1,472 | 2.03 | 2.19 |
AUC0–6 (area under the concentration-time curve from 0 to 6 h) as calculated from time points at 0, 2, 4 and 6 h on day 0 as they were collected on day 6 for purposes of comparison between day 0 and day 6 only.