Table 3.

Spearman's correlation coefficients (ρ) of plasma drug pharmacokinetic and parasitological variables compared to pharmacodynamic outcomes

Pharmacokinetic or parasitological parameter	Spearman's correlation coefficienta
	Parasite clearance time			Parasite reduction ratio			P0
	50%	90%	100%	24 h	48 h	72 h
Parasite density at time zero (P0)	0.204	0.025	0.377	0.002	0.028	−1.410	1.000
PK parameters
AS on day 0
AUC0–8	0.125	0.092	0.067	−0.054	−0.020	−0.049	0.052
Cmax	0.076	0.072	0.058	−0.450	0.004	0.045	0.051
CL/F	−0.058	0.007	0.045	−0.032	−0.119	−0.155	−0.064
V/F	0.050	−0.027	−0.006	0.007	−0.015	−0.067	−0.035
DHA on day 0
AUC0–8	0.125	0.095	0.091	−0.068	−0.068	−0.029	0.073
Cmax	0.079	0.077	0.088	−0.034	−0.064	−0.014	0.064
CL	−1.010	−0.080	−0.090	0.071	0.054	0.048	−0.086
V/F	−0.088	−0.026	−0.060	−0.015	−0.052	−0.012	−0.191
DHA on day 6
AUC	0.027	0.068	0.122	−0.068	−0.087	−0.035	0.014
Cmax	0.010	0.057	0.120	−0.063	−0.077	−0.039	−0.013
CL	0.102	0.054	−0.044	−0.017	−0.018	−0.037	−0.042
V/F	0.034	0.040	−0.022	−0.008	−0.053	−0.013	−0.087
In vitro drug susceptibility (IC50b)
DHA	0.200	0.117	0.223	−0.104	−0.098	−0.217	0.262
AS	0.242	0.157	0.223	−0.118	−0.073	−0.170	0.294
LUM	−0.130	−0.015	−0.012	−0.009	−0.023	0.020	−0.090
CQ	0.057	−0.060	0.041	0.092	0.047	−0.042	0.181
Q	−0.178	−0.149	−0.114	0.123	0.093	0.108	−0.118
MQ	−0.122	−0.040	−0.050	0.006	0.029	0.032	−0.013

^aSpearman's correlation coefficients (ρ) of the indicated pharmacokinetic or parasitological parameter compared to the pharmacodynamic outcomes expressed as 50, 90, and 100% parasite clearance times and parasite reduction ratios at 24, 48, and 72 h. Statistically significant correlations are highlighted in boldface type (P < 0.05).

^bIC₅₀s are 50% inhibitory drug concentrations in vitro.