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. 2012 Nov;56(11):5724–5727. doi: 10.1128/AAC.01333-12

Table 2.

Pharmacokinetics of polymyxin B1 pre- and post-renal insufficiencya

Time of evaluation t1/2 (h) V (ml) CL (ml/min) AUC0–∞ (μg · h/ml)
Pre-renal insufficiency 1.56 ± 0.16 209.10 ± 8.38 1.56 ± 0.21 6.42 ± 0.91
Post-renal insufficiency 1.81 ± 0.40 184.00 ± 44.44 1.17 ± 0.13 8.50 ± 1.07
P 0.47 0.45 0.02 0.004
a

Data are means ± standard deviations. t1/2, elimination half-life; V, volume of distribution; CL, total body clearance; AUC0–∞, area under the serum concentration-time curve from time zero to infinity.