Table 2.
Time of evaluation | t1/2 (h) | V (ml) | CL (ml/min) | AUC0–∞ (μg · h/ml) |
---|---|---|---|---|
Pre-renal insufficiency | 1.56 ± 0.16 | 209.10 ± 8.38 | 1.56 ± 0.21 | 6.42 ± 0.91 |
Post-renal insufficiency | 1.81 ± 0.40 | 184.00 ± 44.44 | 1.17 ± 0.13 | 8.50 ± 1.07 |
P | 0.47 | 0.45 | 0.02 | 0.004 |
Data are means ± standard deviations. t1/2, elimination half-life; V, volume of distribution; CL, total body clearance; AUC0–∞, area under the serum concentration-time curve from time zero to infinity.