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Impact of DprE1 inhibition on the synergy between BTZ043 and TMC207. To determine if synergy between BTZ043 and TMC207 was due to the inhibition of DprE1 by BTZ043 or to an off-target effect, the activities of combinations of BTZ043 and TMC207 were tested on wild-type H37Rv (wt) and on BTZ043-resistant H37Rv which carried a point mutation in DprE1 (C387S). Compound activity was determined by CFU counting. Values represent compound concentrations in ng/ml.
