Table 1.
MICs of selected antituberculosis compounds against M. tuberculosis H37Rv and corresponding interaction profiles with BTZ043 assessed by REMA checkerboard
| Compound | MIC (μg/ml) by REMA | Interaction profile with BTZ043 |
|
|---|---|---|---|
| ΣFIC | Outcome | ||
| BTZ043 | 0.0015 | ||
| Rifampin | 0.0015 | 1.0 | Additive |
| Isoniazid | 0.2 | 1.0 | Additive |
| Ethambutol | 0.6 | 1.0 | Additive |
| TMC207 | 0.08 | 0.5 | Synergistic |
| PA-824 | 0.15 | 1.0 | Additive |
| Moxifloxacin | 0.025 | 1.0 | Additive |
| Meropenem | 2 | 0.75 | Additive |
| Meropenem plus clavulanate | 0.5 | 0.75 | Additive |
| SQ-109 | 0.175 | 1.0 | Additive |