Fig 1.

Percent luciferase signal compared to that for the vehicle-treated control for 527 compounds tested in the initial growth screen, sorted from the most effective inhibitors to the most effective enhancers. Small molecules that were not obviously toxic to host cells and that either inhibited parasite growth by >90% or increased parasite growth by >200% were categorized as inhibitors and enhancers, respectively, and were selected for further assays. Thirty compounds satisfied these criteria.