Table 1.
Name | Compound identifier | Effect | % I/E | EC50 (μM) | Likely target | Compound effect on growth | Motility | Invasion |
---|---|---|---|---|---|---|---|---|
C1 | F1115-0016 | INH | 0.17 ± 0.1 | 1.36 ± 3.54 | Parasite | IRR | INH | INH |
C2 | F1041-0001 | INH | 0.19 ± 0.1 | 1.34 ± 0.27 | Parasite | IRR | NE | NE |
C3 | F3215-0002 | INH | 0.65 ± 0.1 | 0.57 ± 0.06 | Parasite | REV | ENH | NE |
C5 | F0909-0123 | INH | 1.82 ± 2.2 | 1.12 ± 0.18 | Parasite | IRR | INH | NE |
C8 | F0406-1005 | ENH | 205.3 ± 7.6 | 0.14 ± 0.02 | Host cell | IRR | NE | NE |
C11 | F0745-0014 | ENH | 213.8 ± 18.8 | 0.21 ± 0.05 | Host cell | IRR | NE | NE |
C12 | F0862-0340 | ENH | 214.1 ± 31.0 | 1.19 ± 0.22 | Unknown | REV | ENH | NE |
C13 | F3220-0514 | ENH | 220.3 ± 1.3 | 0.38 ± 0.26 | Unknown | REV | NE | NE |
Abbreviations: % I/E, percent inhibition or enhancement compared to vehicle control at 10 μM; IRR, irreversible; REV, reversible; INH, inhibitor; ENH, enhancer; NE, no effect.