Table 2.
Amino acid changes associated with resistance to V-073
| Virus | EC50 | Amino acid change (no. of strains)a |
No. of viruses analyzed | |||||
|---|---|---|---|---|---|---|---|---|
| VP1 |
VP3 |
|||||||
| A, 88 | P, 161 | I, 183 | I, 194b | F, 237c | A, 24 | |||
| VDPV-1 10224 | 10× | S (2) | T (6) | M (1) | V (8) | 20 | ||
| F (3) | ||||||||
| 50× | V (19) | 20 | ||||||
| T (1)d | V (1) | |||||||
| VDPV-1 10235 | 10× | F (9) | V (11) | 20 | ||||
| 50× | F (11) | V (8) | 20 | |||||
| M (1) | ||||||||
| VDPV-2 10230 | 10× | M (11) | V (9) | 20 | ||||
| 50× | M (2) | V (18) | 20 | |||||
| VDPV-3 10805 | 10× | F (3) | L (4) | V (13) | 20 | |||
| 50× | F (12) | L (2) | V (6) | 20 | ||||
| Totals | 10× (%) | 2 (2) | 6 (8) | 27 (34) | 4 (5) | 41 (51) | 80 | |
| 50× (%) | 1 (1) | 0 (0) | 0 (0) | 26 (32) | 2 (2) | 52 (65) | 80 | |
| Total (%) | 1 (1) | 2 (1) | 6 (4) | 53 (33) | 6 (4) | 93 (58) | 160 | |
a
Values for VP1 and VP3 are expressed as amino acidchanges (number of changes) except as noted for the totals in column 1. Columnsubheadings indicate the “wild amino acid, residue number.”
b
Equivalent residue 192 in type 3.
c
Equivalent residue 236 in type 3.
d
One virus had changes at both residues, VP188and VP324.