Figure 4.

MRI and histopathological examination from Day 3 after thrombus induction. Most of the thrombus shows isointensity, except for the peripheral portion which shows hyperintensity on (a) axial spin-echo T₁ weighted image [repetition time/echo time (TR/TE), 500/8.0] (arrow). The thrombus shows hypointensity on (b) axial fast spin-echo T₂ weighted image (TR/TE), 4000/98.0] and (c) axial single shot, spin-echo echo-planar diffusion-weighted image (TR/TE, 5000/98.7; b value, 400 s mm⁻²) (arrows). (d) Photomicrograph shows the infiltration of fibroblasts in addition to inflammatory cells including the macrophages into peripheral portion of the thrombus (arrows) (haematoxylin–eosin stain; original magnification,×400). T, thrombus; V, vessel wall.