Trajectories of CES-D10 scores during follow-up according to baseline leptin.
a Estimated trajectories are adjusted for age, race, education level, alcohol consumption, smoking status, physical activity, 3MS score, number of chronic diseases, CVD, diabetes, visceral fat, (log)IL-6 and (log)CRP.
Men: main effect, high leptin: p=0.40; time: p<0.0001; time2: p<0.0001; interaction term, high leptin-by-time: p=0.02.
Women: main effect, high leptin: p=0.58; time: p<0.0001; time2: p<0.0001; interaction term, high leptin-by-time: p=0.68.
b High leptin: >10.1 ng/mL in men and >28.9 ng/mL in women.
Abbreviations: CES-D10, Center for Epidemiological Studies-Depression Scale 10-item.