Table 1.
EC50, TD50 and TI values of Compounds 1 – 6 from MC65 cell protection assays.29
| Compound | EC50 (μM) | TD50 (μM) | TI |
|---|---|---|---|
| 1 | 0.120 ± 0.015 | 39.0 ± 1.12 | 325 |
| 2a | 3.24 ± 0.160 | 37.3 ± 1.77 | 11.5 |
| 2b | 0.070 ± 0.002 | 49.3 ± 0.127 | 704 |
| 2c | 2.77 ± 0.191 | >50 | >18.1 |
| 2d | 24.5 ± 1.31 | >50 | >2.04 |
| 2e | 0.101 ± 0.004 | >50 | >495 |
| 2f | 6.41 ± 0.961 | 39.4 ± 1.87 | 6.15 |
| 2g | 0.769 ± 0.033 | >50 | >65.0 |
| 2h | 2.79 ± 0.107 | 48.0 ± 0.080 | 17.2 |
| 2i | >50 | >50 | – |
| 2j | 4.36 ± 0.055 | 38.2 ± 1.02 | 8.76 |
| 3a | 2.44 ± 0.111 | 30.7 ± 0.429 | 12.6 |
| 3b | 4.66 ± 0.339 | >50 | >10.7 |
| 3c | 0.242 ± 0.014 | 26.3 ± 1.34 | 109 |
| 3d | 3.85 ± 0.416 | >50 | >13.0 |
| 3e | 0.639 ± 0.001 | >50 | >78.2 |
| 3f | 0.067 ± 0.002 | >50 | >746 |
| 3g | 1.56 ± 0.025 | >50 | >32.1 |
| 3h | 0.662 ± 0.070 | 9.38 ± 0.217 | 14.2 |
| 3i | 1.18 ± 0.010 | >50 | >42.4 |
| 3j | 1.26 ± 0.182 | >50 | >39.7 |
| 4a | 0.145 ± 0.002 | 13.7 ± 0.704 | 94 |
| 4b | 0.621 ± 0.051 | 15.3 ± 0.183 | 24.6 |
| 4c | 0.198 ± 0.013 | 26.4 ± 0.264 | 133 |
| 4d | 0.586 ± 0.045 | 18.2 ± 1.84 | 31.1 |
| 5 | 0.459 ± 0.026 | 24.1 ± 1.48 | 52.5 |
| 6a | >50 | 8.35 ± 0.319 | – |
| 6b | 6.25 ± 0.171 | 6.69 ± 0.105 | 1.07 |