Table 1.

HPTN 052 Implementation Status of WHO 2009 Guidelines for ART Initiation^*

Site	Implementation Status
SOUTH AMERICA
Brazil	Threshold is at CD4 <350
ASIA
India	Threshold is currently at CD4 <350 for HIV/TB (pulm) co-infected, and pregnant women with WHO stage 3 disease, and Stage 4 disease or HIV with extra-pulmonary TB initiate ART irrespective of CD4 cell count. General population threshold to increase to CD4 < 350 soon.
Thailand	Current CD4 threshold for the general population is <200. Threshold increase to CD4 <350 for asymptomatic HIV positive person will be reconsidered next year (2012). In order to initiate ART now at CD4 <350, a person needs to have some specific illnesses that are related to HIV/AIDS or WHO stage 4 diseases.
AFRICA
Botswana	Threshold remains at CD4 <250. Botswana National Subcommittee on Clinical Guidelines is awaiting assurance of resources before considering increasing the threshold.
Kenya	Threshold increased to CD4 <350 in late 2010, and is currently being implemented at local clinics.
Malawi	Current CD4 threshold for the general population is <250. Threshold is currently at CD4 <350 for pregnant and breastfeeding women. Any person with WHO stage 3 or stage 4 disease is eligible regardless of CD4 count.
South Africa	Threshold remains at CD4 <350 for HIV/TB co-infected, and pregnant women with CD4 <350 or have WHO stage 3 or 4 disease.
Zimbabwe	Due to resource constraints, the MOH released guidelines in March 2011 for a phased-approach of implementation of ART initiation for CD4 <350 over next three years, starting 01 April 2011.

^*Current as of April 2011