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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Eur J Neurosci. 2011 Nov 18;34(11):1767–1782. doi: 10.1111/j.1460-9568.2011.07890.x

Fig. 6.

Fig. 6

Impaired spatial memory and motor deficits in GADcre/+;Nkx2-1fl/fl mice and learning deficits in female ChATcre/+;Nkx2-1fl/fl mice. (A) Escape latencies during the place and cued version (v.) of the Morris water maze (MWM) are shown for female and male GADcre/+;Nkx2-1fl/fl and Nkx2-1fl/fl mice. Female and male mutant mice failed to learn the location of the platform. Data are presented as means ± SEM; *P < 0.05 vs. Nkx2-1fl/fl. (B) The time (spatial probe of the MWM) spent in the platform quadrant (PQ) and the mean time spent in the three other quadrants (MQ) are presented for female and male GADcre/+;Nkx2-1fl/fl and Nkx2-1fl/fl mice. Female and male mutant mice failed to remember the former location of the platform, but control mice also showed slight deficits in spatial memory. Data are presented as means + SEM. (C) Rota-rod test for female and male Nkx2-1fl/fl and GADcre/+;Nkx2-1fl/fl mice. The time spent on the rotating rod is shown for all mutants in comparison with control mice. Data are presented as mean + SEM; *P < 0.05 vs. Nkx2-1fl/fl. (D) Representative paths followed by a female Nkx2-1fl/fl control and a female GADcre/+;Nkx2-1fl/fl mutant mouse on the third day of the place version. (E) Escape latencies during the place and cued version (v.) of the MWM for female and male Nkx2-1fl/fl and ChATcre/+;Nkx2-1fl/fl mice are shown. Female ChATcre/+;Nkx2-1fl/fl mice needed more time to find the platform than female control mice on days 6 and 8. Data are presented as mean ± SEM; *P < 0.05 vs. Nkx2-1fl/fl. (F) The time (spatial probe of the MWM) spent in the platform quadrant (PQ) and the mean time spent in the three other quadrants (MQ) is presented for female and male Nkx2-1fl/fl and ChATcre/+;Nkx2-1fl/fl mice. Only female mutant mice failed to remember the former location of the platform. No difference in the performance of male ChATcre/+;Nkx2-1fl/fl and Nkx2-1fl/fl mice was detected. Data are presented as mean + SEM; *P < 0.05 vs. PQ. (G) The time spent on the rotating rod is plotted on the diagram for female and male Nkx2-1fl/fl and ChATcre/+;Nkx2-1fl/fl mice. No differences between mutants and control mice were detected. Data are presented as mean + SEM. (H) Representative paths followed by a female Nkx2-1fl/fl control and a female ChATcre/+;Nkx2-1fl/fl mutant mouse on day 3 of the place version.