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. 2012 Nov 1;8(11):e1002755. doi: 10.1371/journal.pcbi.1002755

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© 2012 Dana, Tuller

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The green round shapes represent the ribosomes on the mRNA, which is depicted with a blue line. According to the biophysical model, segments of high ribosomal read counts are associated with regions more slowly translated (bottom graph). The orange double arrows represent the mRNA segments being translated in equal time intervals. (B). histogram calculated on real (blue) and simulated ribosomal profiles for low/high/proportional initiation rates (black/red/green) with zero noise level. The calculated median value of this measure is 88/2.46/2.39/2.38 accordantly.

Inline graphic — The green round shapes represent the ribosomes on the mRNA, which is depicted with a blue line. According to the biophysical model, segments of high ribosomal read counts are associated with regions more slowly translated (bottom graph). The orange double arrows represent the mRNA segments being translated in equal time intervals. (B). histogram calculated on real (blue) and simulated ribosomal profiles for low/high/proportional initiation rates (black/red/green) with zero noise level. The calculated median value of this measure is 88/2.46/2.39/2.38 accordantly.