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. 2012 Nov 1;8(11):e1002764. doi: 10.1371/journal.pcbi.1002764

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© 2012 Zhu, Mogilner

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–B) Snapshots of hybrid model simulations. Blue: obstacles. White: actin networks. Dark gray: rigid substrate. Bars: . (A) Actin network grows continuously against a flat cantilever with force being proportional to the deflection. (B) Actin network grows against a spherical bead, with force being clamped for each velocity measurement. (C–D) Simulated force-velocity relation compared with the data. (C) Computational results corresponding to the setup in (A). Red circles: experimental data from [19]. Solid line: hybrid model simulation. Dashed line: prediction of the 1D theory in Text S1. Dotted line: approximate analytical formula . (D) Computational results corresponding to the setup in (B). Red circles: experimental data from [18]. Solid line: hybrid model. Dashed line: prediction of the 1D theory in Text S1.

Inline graphic — (A–B) Snapshots of hybrid model simulations. Blue: obstacles. White: actin networks. Dark gray: rigid substrate. Bars: . (A) Actin network grows continuously against a flat cantilever with force being proportional to the deflection. (B) Actin network grows against a spherical bead, with force being clamped for each velocity measurement. (C–D) Simulated force-velocity relation compared with the data. (C) Computational results corresponding to the setup in (A). Red circles: experimental data from [19]. Solid line: hybrid model simulation. Dashed line: prediction of the 1D theory in Text S1. Dotted line: approximate analytical formula . (D) Computational results corresponding to the setup in (B). Red circles: experimental data from [18]. Solid line: hybrid model. Dashed line: prediction of the 1D theory in Text S1.