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Effect of drug on DMN. Compared to baseline, nicotine was associated with decreased activity in precuneus, posterior cingulate, and medial frontal cortex (left). Placebo was associated with a smaller region of decreased activity in posterior cingulate (right). Maps set at threshold p<0.001, masked with effect of condition set at p<10–6. Colored bars represent weighted contrast t-scores for within-subject rmANOVA
