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. 2012 Jul 23;590(Pt 19):4717–4733. doi: 10.1113/jphysiol.2012.234229

Figure 4. CB1 receptor agonists cause a specific inhibition of high-threshold primary afferent EPSCs.

Figure 4

A, inhibition of high-threshold EPSCs (threshold ≥ 15 V) by CP 55,940 (3 μm). Left, time course. Right, averages traces of 10 consecutive EPSCs before application of CP 55,940 (black, control) and after (CP, red). B, same as A but low-threshold EPSCs (threshold < 15 V). C, degree of EPSC inhibition plotted versus the stimulation threshold of the EPSC (black, WIN 55,212-2; red CP 55,940). D, per cent EPSC inhibition by CP 55,940 and WIN 55,212-2 in low-threshold and high-threshold EPSCs. The difference between high-threshold EPCSs (≥15 V) and low-threshold EPSCs (<15 V) was statistically significant (P≤ 0.0001, unpaired Student's t test), while differences between WIN 55,212-2 and CP 55,940 were small and remained below statistical significance (P= 0.95 and P= 0.34, for low-threshold and high-threshold EPSCs).