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. 2012 Aug 13;590(Pt 19):4761–4775. doi: 10.1113/jphysiol.2012.232470

Figure 8. Blockade of ASIC current within the caudal NTS reduces respiratory motor output during hypercapnia (end-tidal Inline graphic = 54 mmHg).

Figure 8

A, injection of amiloride (2 × 10−10 mol in 200 nl) centred in the medial NTS (SolM) 300 μm rostral to obex, transiently reduces phrenic nerve burst frequency (Resp Rate) and arterial pressure (AP) but has little effect on the peak amplitude of integrated phrenic nerve activity (∫Phr) or heart rate (HR). B, peak changes in cardiorespiratory variables during injection of amiloride compared to hypercapnic control. *Significant decrease in respiratory rate vs. control (P < 0.05). C, coronal, pseudocoloured image of the injection site in SolM for the rat shown in A. Monochrome image of the rhodamine impregnated microspheres (red) and the darkfield image (green) were inserted into the red and green channels of a digital image. 10N, dorsal motor nucleus of the vagus; 12N, hypoglossal nucleus; AP, area postrema; cc, central canal; Gr, gracile nucleus; sol, solitary tract.