Fig 2 Effect of various model assumptions on cost per additional residual recurrent cervical intraepithelial neoplasia (CIN) 3+ case averted, compared with cytology only follow-up. HPV=human papillomavirus; LBC=liquid based cytology. *Under perfect compliance assumptions, this strategy was predicted to result in more underlying CIN3+ at 10 years than cytology only follow-up, so cost per underlying case of CIN3+ averted should be interpreted as cost per underlying case of CIN3+ averted by cytology only follow-up compared with HPV testing strategy. †Population composition (age structure and proportion treated for CIN1 v CIN2+) was varied to reflect different post-treatment populations observed in HPV Sentinel Sites Study and in a recent study of post-treatment management.² Baseline analyses reflected HPV sentinel sites population, in which 63% of treated women were younger than 35 years and 10% of women were treated for CIN1 and the remainder for CIN2+. The “younger” population had a higher proportion of treated women aged <35 years (73%), consistent with that observed in a previous study²; the “more CIN1” population had a higher proportion of women treated for CIN1 (23.6%), consistent with that observed in a previous study.² ‡Sensitivity and specificity varied within feasible range. §Effect on outcomes was too small to show substantial variation in this depiction. ¶Negative values indicate that strategy prevents more cases and is cost saving compared with cytology only follow-up