Table 2.
Drugs | Enzyme | Cancer |
---|---|---|
Cisplatin | GSTM, GSTT | Breast |
Cyclophosphamide | CYP2B6, CYP2C19, CYP3A4 | Leukemia, lymphoma |
Dacarbazine | CYP1A1, CYP1A2, CYP2E1 | Melanoma, sarcoma, lymphoma |
Docetaxel | CYP2C8, CYP3A, CYP1B1 | Breast, lung, stomach |
Doxorubicin | CYP3A4 | Sarcoma |
Ellipticine | CYP3A4, CYP1A | Leukemia, myeloma, lymphosarcoma |
Etoposide | CYP3A4, CYP2E1, CYP1A2 | Testicle, lung, breast, leukemia, lymphoma |
Ifosfamide | CYP2B6, CYP3A4 | Sarcoma, testicle |
Imatinib | CYP3A4, CYP3A5 | Leukemia |
Irinotecan | CYP3A4/5 | Colon and rectum |
UGT1A1 | ||
Methotrexate | MTHFR | Leukemia |
Mitoxantrone | CYP3A4, CYP1B1 | Leukemia, lymphoma |
Paclitaxel | CYP2C8, CYP3A4 | Breast, lung, ovary |
Phortress (2-(4-aminophenyl-benzotiazol) | CYP1A1, CYP1B1 | Ovary, breast |
Procarbazine | CYP1A1, CYP2B6 | Lymphoma, brain, lung, melanoma, testicle |
Tamoxifen | CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP1B1, UGT2B7 | Breast |
Tegafur | CYP2A6, CYP2C8, CYP1A2 | Colon, rectum, stomach |
Teniposide | CYP2C19, CYP3A4/5 | Leukemia, lung, brain, bladder, myeloma |
Thiotepa | CYP2B6, CYP3A4 | Bladder |
Topotecan | CYP3A4/5 | Ovary, lung |
Vinblastine | CYP3A4/5 | Lymphoma, osteosarcoma |
Vincristine | CYP3A4/5 | Lymphoma |
Vindesine | CYP3A4/5 | Lung |
Vinrelbine | CYP3A4/5 | Lung |