Table 3.
Genotype and allele frequencies of CYP1A1, CYP1A2, CYP2A6, CYP3A4/5, CYP2C8, CYP2C9, CYP2C19, CYP2E1, CYP2D6, UGT2B7, GSTM1, GSTT1 y MTHFR polymorphisms in a Chilean mestizo population.
| CYP1A1*2A | n | % | CYP1A1*2C | n | % | CYP1A2*1F | n | % | CYP2A6*2 | n | % | CYP2A6*3 | n | % | CYP2A6*4 | n | % |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| *1/*1 | 112 | 44.27 | *1/*1 | 79 | 43.89 | *1A/*1A | 18 | 7.11 | *1A/*1A | 244 | 100.00 | *1A/*1A | 253 | 100.00 | *1A/*1A | 244 | 100.00 |
| *1/*2A | 95 | 37.55 | *1/*2C | 86 | 47.78 | *1A/*1F | 81 | 32.02 | *1A/*2 | 9 | 0.00 | *1A/*3 | 0 | 0.00 | *1A/*4 | 0 | 0.00 |
| *2A/*2A | 46 | 18.18 | *2C/*2C | 15 | 8.33 | *1F/*1F | 154 | 60.87 | *2/*2 | 0 | 0.00 | *3/*3 | 0 | 0.00 | *4/*4 | 9 | 0.00 |
| TOTAL | 253 | 100.0 | TOTAL | 180 | 100.00 | TOTAL | 253 | 100.00 | TOTAL | 253 | 100.00 | TOTAL | 253 | 100.00 | TOTAL | 253 | 100.00 |
| fwt | 0.63 | f*1 | 0.68 | f*1A | 0.23 | f*1A | 0.98 | f*1A | 1.00 | f*1A | 0.96 | ||||||
| f*2A | 0.37 | f*2C | 0.32 | f*1F | 0.77 | f*2 | 0.02 | f*3 | 0.00 | f*4 | 0.04 | ||||||
| CYP2C8*3 | n | % | CYP2C9*2 | n | % | CYP2C9*3 | n | % | CYP2C19*2 | n | % | CYP2C19*3 | n | % | CYP2D6*2 | n | % |
| *1A/*1A | 157 | 87.22 | *1A/*1A | 225 | 88.93 | *1A/*1A | 167 | 92.78 | *1A/*1A | 201 | 79.45 | *1A/*1A | 253 | 100.00 | *1A/*1A | 88 | 34.78 |
| *1A/*3 | 23 | 12.78 | *1A/*2 | 26 | 10.28 | *1A/*3 | 13 | 7.22 | *1A/*2 | 44 | 17.39 | *1A/*3 | 0 | 0.00 | *1A/*2 | 121 | 47.83 |
| *3/*3 | 0 | 0.00 | *2/*2 | 2 | 0.79 | *3/*3 | 0 | 0.00 | *2/*2 | 8 | 3.16 | *3/*3 | 0 | 0.00 | *2/*2 | 44 | 17.39 |
| TOTAL | 180 | 100.00 | TOTAL | 253 | 100.00 | TOTAL | 180 | 100.00 | TOTAL | 253 | 100.00 | TOTAL | 253 | 100.00 | TOTAL | 253 | 100.00 |
| f*1A | 0.94 | f*1A | 0.94 | f*1A | 0.96 | f*1A | 0.88 | f*1A | 1.00 | f*1A | 0.59 | ||||||
| f*3 | 0.06 | f*2 | 0.06 | f*3 | 0.04 | f*2 | 0.12 | f*3 | 0.00 | f*2 | 0.41 | ||||||
| CYP2D6*3 | n | % | CYP2D6*4 | n | % | CYP2E1*5B | n | % | CYP2E1*6 | n | % | CYP3A4*1B | n | % | CYP3A4*17 | n | % |
| *1A/*1A | 248 | 98.02 | *1A/*1A | 198 | 78.26 | *1A/*1A | 135 | 75.00 | *1A/*1A | 123 | 68.33 | *1A/*1A | 225 | 88.93 | *1A/*1A | 253 | 100.00 |
| 1A/*3 | 5 | 1.98 | 1A/*4 | 50 | 19.76 | *1A/*5B | 39 | 21.67 | *1A/*6 | 45 | 25.00 | *1A/*1B | 28 | 11.07 | *1A/*17 | 0 | 0.00 |
| *3/*3 | 0 | 0.00 | *4/*4 | 5 | 1.98 | *5B/*5B | 6 | 3.33 | *6/*6 | 12 | 6.67 | *1B/*1B | 0 | 0.00 | *17/*17 | 0 | 0.00 |
| TOTAL | 253 | 100.00 | TOTAL | 253 | 100.00 | TOTAL | 180 | 100.00 | TOTAL | 180 | 100.00 | TOTAL | 253 | 100.00 | TOTAL | 253 | 100.00 |
| f*1A | 0.99 | f*1A | 0.88 | f*1A | 0.86 | f*1A | 0.81 | f*1A | 0.95 | f*1A | 1.00 | ||||||
| f*3 | 0.01 | f*4 | 0.12 | f*5B | 0.14 | f*6 | 0.19 | f *1B | 0.06 | f*17 | 0.00 | ||||||
| CYP3A5*3 | n | % | MTHFR (C677T) | n | % | UGT2B7*2 | n | % | GSTM1 | n | % | GSTT1 | n | % | |||
| *1A/*1A | 17 | 6.72 | CC | 36 | 20.00 | *1/*1 | 68 | 26.88 | null | 161 | 63.64 | null | 160 | 88.88 | |||
| *1A/*3 | 86 | 33.99 | CT | 100 | 55.56 | *1/*2 | 170 | 67.19 | null | 92 | 36.36 | null | 20 | 11.11 | |||
| *3/*3 | 150 | 59,29 | TT | 44 | 20.00 | *2/*2 | 15 | 5.93 | TOTAL | 253 | 100.00 | TOTAL | 180 | 100.00 | |||
| TOTAL | 253 | 100.00 | TOTAL | 180 | 24.44 | TOTAL | 253 | 100.00 | |||||||||
| f*1A | 0.24 | fc | 0.48 | f*1 | 0.60 | ||||||||||||
| f*3 | 0.76 | ft | 0.52 | f*2 | 0.40 | ||||||||||||