Table 1.
TEV of Single SNPs and Multi-SNPs for Each Anthropometric-Trait Phenotype
| Trait | p Value | Number of Loci (FDR) |
TEV |
Number of Replicated Loci |
||
|---|---|---|---|---|---|---|
| Single SNP | Multi-SNP | Single SNP | Multi-SNP | |||
| Height | p < 5 × 10−8 | 106 (0.0%) | 4.10% | 6.93% | 93 | 96 |
| p < 1 × 10−2 | 2,073 (80.0%) | 6.88% | 13.52% | 142 | 186 | |
| BMI | p < 5 × 10−8 | 18 (7.0%) | 0.92% | 1.02% | 15 | 16 |
| p < 1 × 10−2 | 2,031 (95.0%) | 1.96% | 3.61% | 15 | 25 | |
| WHR | p < 5 × 10−8 | 2 (0.0%) | 0.09% | 0.09% | 2 | 2 |
| p < 1 × 10−2 | 1,985 (100.0%) | 0.12% | 2.22% | 0 | 2 | |
These estimates account for the number of SNPs constituting the multi-SNP association. FDR was estimated with the Bayes’ theorem (for details, see Supplemental Data section 4). The following abbreviations are used: FDR, false discovery rate; TEV, total explained variance; BMI, body mass index; and WHR, waist-to-hip ratio.