Fig. 2.

Changes in serum creatinine (SC) levels in animals treated with warfarin. A Control (solid squares, n = 11), B 5/6 nephrectomy rats 3 weeks after the ablative surgery (5/6NE 3W, n = 7), C 5/6 nephrectomy rats 8 weeks after the ablative surgery (5/6NE 8W, n = 10) and D 5/6 nephrectomy rats 19 weeks after the ablative surgery (5/6NE 19W, n = 6) were treated with increasing doses of warfarin (doses and time are shown in rectangles on the x-axis). Changes in SC levels in animals treated with warfarin (+ warfarin) (solid line, solid squares, A–D) were compared with SC levels in animals treated with vehicle (+ vehicle) (dotted line, solid circles, B–D) at the same time after the ablative surgery as the warfarin-treated animals. * p < 0.05 compared to vehicle-treated animals.